Fasting alters p75NTR and AgRP mRNA expression in rat olfactory bulb and hippocampus

Classic non-homeostatic structures involved in food intake regulation are reciprocally influenced by metabolic signals. Orexigenic peptides expressed the olfactory bulb (OB) and hippocampus (HP) modulate processing memory, respectively. Hypothalamic circuits also feeding behavior activating releasing Agouti-related peptide (AgRP) response to orexigenic An adequate fasting requires expression of p75 neurotrophin receptor (p75NTR) AgRP neurons. The present study aimed determine whether there is a role for p75NTR OB HP on fasted rats. A group rats (FG) was confronted with decision-making paradigm T-maze containing standard chow pellet (CP), same coated phenolic-rich avocado paste extract (AVO) either end; their were then analyzed histological molecular tools. FG had briefer latencies, as compared control fed ad libitum (median latencies: 55.4 vs 191.7 min, p = 0.032). They reduced cell counts both brain structures, satiated mRNA not group, however, it found OB. These results suggest that contrasting states (fasted or satiated) motivate different responses, which structures.